Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (38): 7048-7050.doi: 10.3969/j.issn.1673-8225.2010. 38.005

Previous Articles     Next Articles

Comparison on promoting revascularization of DegraPol scaffold covered by omentum and subcutaneous in vivo

Yang Lin, Wu Yan-ge, Sun Xue-feng, Wang Zheng   

  1. Department of Thoracic Surgery, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University, Shenzhen   518020, Guangdong Province, China　
  • Online:2010-09-17 Published:2010-09-17
  • About author:Yang Lin☆, Post-doctor, Director Doctor, Department of Thoracic Surgery, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China Yanglin70@yahoo.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30500499*

PDF

353

Abstract:

BACKGROUND: How to solve rapid vascularization is the key to success of tissue engineering when the tissue engineered organs are implanted into body.
OBJECTIVE: To compare the difference of revascularization between the tissue engineered scaffold DegraPol covered by omentum and subcutaneous, and to find an effective method for rapid revascularization in vivo.
METHODS: Using the anatomic technology of vascular cast, revascularization of DegraPol scaffold implanted by omentum and subcutaneously was compared.
RESULTS AND CONCLUSION: More blue developing micro-capillary vessels wrapped the outer DegraPol scaffolds in omental implants than in subcutaneous implants. In porous scaffold, relative abundant new vessels formed in omental implant group. Subcutaneous implant group found no neovacularization. The vascularization degree of omentum implant was significantly higher than subcutaneous implant (P < 0.05). Omentum is effective in promoting to establish blood circulation, can be used as a viable method of tissue engineered revascularization.

CLC Number: